@Robert Miller good question, and it's exactly the right thing to be thinking about before you commit your layout.
The MultiNav Pro+ is designed to be a complete RF front-end — the amplifiers, matching, and filtering are all handled on-module, so you're not expected to drop a Pi network between the module output and your antenna connector. The 50km spec is drone-to-drone with both units elevated (ground reflections eliminated), so the RF chain on the module itself is already optimized for that. What you do need to get right on your end is the transmission line from the module's antenna port to your connector — keep it as short as possible, maintain 50 ohm impedance on that trace, and avoid any stubs or right-angle bends near the RF path.
The thing that kills range in these integrations more often than matching issues is ground plane discontinuity under the RF trace and nearby copper pours that aren't properly stitched. If you post your layout I'm happy to take a look, or hit up the Dev Hub resources section — there's documentation in there that should give you the antenna interface specifics you need.