@James Rodriguez great question, and yeah that 3-4dB hit from lazy matching is exactly the kind of thing that kills range on paper-spec modules.
The MultiNav Pro+ ships with the RF front-end pre-matched and optimized — that's actually a big part of how it hits the range figures it does, because Moamen tuned the matching for real-world deployment, not just the reference board. The external LNA and PA are already integrated and matched on the module itself, so you don't need to budget space for a Pi network between the module and your antenna feed point.
That said, you'll still want to keep your antenna feed line as short and clean as possible and make sure your PCB antenna or connector launch is reasonably well-controlled impedance-wise — the module can't compensate for a bad 50-ohm trace on your side. If you're using an external antenna via U.FL or SMA, keep that launch clean and you should be fine without any additional matching components.
If you want to be totally sure for your specific layout, worth posting your antenna approach here — someone in the community or Moamen himself might have seen a similar layout before.